2023
Lim K, Rutherford EN, Sun D, Van den Boomen DJH, Edgar JR, Bang JH, Matesic LE, Lee JH, Lehner PJ, Marciniak SJ, Rawlins EL, Dickens JA. A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease. bioRxiv [Preprint]. 2023 Sep 4:2023.08.30.555522. DOI: 10.1101/2023.08.30.555522.
Liu S, Sun D, Butler R, Rawlins EL. RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells. Development Published online May 23, 2023. DOI: 10.1242/dev.201284.
Lim K., Donovan A.P.A., Tang W., Sun D., He P., Teichmann S.A., Marioni J.C., Meyer K.B., Brand A.H., and Rawlins E.L. (2023). Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease. Cell Stem Cell 30, 1-18. Published online December 8, 2022. DOI: 10.1016/j.stem.2022.11.013.
2022
He P., Lim K.. Sun D., Pett J.P. , Jeng Q., Polanski K., Dong Z., Bolt L., Richardson L., Mamanova L., Dabrowska M., Wilbrey-Clark A., Madissoon E., Tuong Z.K., Dann E., Suo C., Goh I., Yoshida M., Nikolić M.Z., Janes S.M., He X., Barker R.A., Teichmann S.A., Marioni J.C., Meyer K.B., Rawlins E.L. (2022) A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates. Cell 185(25): 4841-4860.e25. DOI: 10.1016/j.cell.2022.11.005.
Sun D., Llora Batlle O., van den Ameele J., Thomas J.C., He P., Lim K., Tang W., Xu C., Meyer K.B., Teichmann S.A., Marioni J.C., Jackson S.P., Brand A.H., Rawlins E.L., 2022. SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling. The EMBO Journal 41:e111338. DOI: 10.15252/embj.2022111338.
Shuyu L., Sun D., Butler R., Rawlins E.L., 2022. RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells. bioRxiv. Ahead of publication.
Clements-Brod N., Holmes L., Rawlins E.L., 2022. Exploring the challenges and opportunities of public engagement with fundamental biology. Development 149 (18).
2021
Sun D., Evans L., Perrone F., Sokleva V., Lim K., Rezakhani S., Lutolf M., Zilbauer M., Rawlins E.L., 2021. A functional genetic toolbox for human tissue-derived organoids. eLife. 2021;10:e67886. PMCID: PMC8553336.
2019
Schiller, H.B., Montoro, D.T., Simon, L.M., Rawlins, E.L., Meyer, K.B., Strunz, M., Vieira Braga, F.A., Timens, W., Koppelman, G.H., Budinger, G.R.S., Burgess, J.K., Waghray, A., van den Berge, M., Theis, F.J., Regev, A., Kaminski, N., Rajagopal, J., Teichmann, S.A., Misharin, A.V., Nawijn, M.C., 2019. The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease. Am J Respir Cell Mol Biol 61, 31-41. (Comment article)
2018
Ma D., Wang B., Zawadzka M., Gonzalez G., Wu Z., Yu B., Rawlins E.L., Franklin R.J.M., Zhao C. A subpopulation of Foxj1-expressing, nonmyelinating Schwann cells of the peripheral nervous system contribute to Schwann cell remyelination in the central nervous system. (2018) J. Neurosci. 38, 9228-9239. PMCID: PMC6199410.
Johnson JA, Watson JK, Nikolić MZ, Rawlins E.L.. Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium. Biol Open. 2018 Apr 16;7(4). pii: bio033944. doi: 10.1242/bio.033944. PMCID: PMC5936064
Nikolić M.Z., Sun, D. and Rawlins E.L. Human lung development: recent progress and new challenges. (2018) Development 145, dev163485. doi:10.1242/dev.163485 (Review article)
Lee J-H and Rawlins E.L. Developmental mechanisms and adult stem cells for therapeutic lung regeneration. (2018) Developmental Biology 433, 166-176. (Review article).
2017
Nikolić M.Z., Caritg O., Jeng Q., Johnson J., Sun D., Howell, K.J., Brady J.L., Laresgoiti U., Allen G., Butler R., Zilbauer M., Giangreco A., Rawlins E.L. (2017) Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids. Elife. 2017 Jun 30;6. pii: e26575. doi: 10.7554/eLife.26575. PMCID: PMC5555721
Balasooriya G.I., Goschorska M., Piddini E, Rawlins E.L. (2017) FGFR2 is required for airway basal cell self-renewal and terminal differentiation. Development 144, 1600-1606. PMCID: PMC5450841
Correia L.L., Johnson J., Farah H., Rassl D.M., Rintoul R., Sethi T., Rawlins E.L., Littlewood T.D., Evan G.I., McCaughan, F.M. SOX2 drives bronchial dysplasia in a novel organotypic model of early squamous lung cancer. 2017. American Journal of Respiratory and Critical Care Medicine doi: 10.1164/rccm.201510-2084OC. [Epub ahead of print].
Huch M. and Rawlins E.L. Tumours build their niche. Nature 2017 May 18;545(7654):292-293. (Commentary)
Nikolić M.Z., Rawlins E.L. Lung organoids and their use to study cell-cell interaction. Current Pathobiology Reports 2017;5(2):223-231. (Review article)
2016
Laresgoiti U., Nikolić M.Z., Rao C., Brady J.L., Richardson R.V., Batchen E.J., Chapman K.E. and Rawlins E.L. (2016) Lung epithelial tip progenitors integrate Glucocorticoid and STAT3-mediated signals to control progeny fate. Development 143, 3686-3699. PMCID: PMC5087639.
Rognoni E., Gomez C., Oliveira Pisco A., Rawlins E.L., Simons B.D., Watt F.M., and Driskell R.R. (2016) Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing. Development 143, 2522-2535. PMCID: PMC4958333.
Balasooriya G.I, Johnson J., Basson M.A., Rawlins E.L. (2016) An FGFR1-SPRY2 signalling axis limits basal cell proliferation in the steady-state airway epithelium. Developmental Cell 37, 85-97. PMCID: PMC4825408.
Wagstaff L., Goschorska M., Kozyrska K., Duclos G., Kucinski I., Chessel A., Hampton-O’Neil L., Bradshaw C.R., Allen G.E., Rawlins E.L., Silberzan P., Carazo Salas R.E. and Piddini E. (2016) Mechanical cell competition kills cells via induction of lethal p53 levels. Nature Communications 7, 11373. PMCID: PMC4848481.
Nikolić M.Z., Rawlins E.L. Synthetic scaffolds help airway cells reach maturity. (2016) eLife doi: 10.7554/eLife.21786. PMCID: PMC5089856 (Commentary)
2015
Watson, J.K., Rulands S., Wilkinson A. C., Wuidart A., Ousset M., Van Keymeulen A., Göttgens B., Blanpain C., Simons B.D., Rawlins E. L., (2015). Clonal dynamics reveal two distinct populations of basal cells in slow turnover airway epithelium. Cell Reports 12, 90-101. PMCID: PMC4518462.
Rawlins, E.L. Stem cells: Emergency back-up for lung repair. (2015) Nature 517, 556-557. (Commentary)
2014
Rawlins E.L., Giangreco A. The best laid schemes of airway repair. (2014) Eur Respir J 44, 299-301. (Commentary)
2012
Hoyler, T., Klose, C. S., Souabni, A., Turqueti-Neves, A., Pfeifer, D., Rawlins, E. L., Voehringer, D., Busslinger, M., and Diefenbach, A. The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. (2012) Immunity 37, 634-648. PMCID: PMC3662874.
Rawlins E. L., and Perl A. K. The a"MAZE"ing World of Lung-Specific Transgenic Mice. (2012) Am J Respir Cell Mol Biol 46, 269-282. PMCID: PMC3785140. (Review article)
2011
Onaitis M., D'Amico T.A., Clark C., Guinney J., Harpole D.H., and Rawlins E.L. A 10-gene progenitor cell signature predicts prognosis in lung adenocarcinoma. (2011) Annals of Thoracic Surgery, 91, 1046-50. PMCID: PMC3376444.
Paez-Gonzalez, P., Abdi, K., Luciano, D., Liu, Y., Soriano-Navarro, M., Rawlins, E. L., Bennett, V., Garcia-Verdugo, J. M., and Kuo, C. T. Ank3-dependent SVZ niche assembly is required for the continued production of new neurons. (2011) Neuron 71, 61-75. PMCID: PMC3134799.
Rawlins E. L. The building blocks of mammalian lung development. (2011) Developmental Dynamics 240, 463-476. (Review article)
2009
Rawlins E. L., Clark C. P., Xue Y., and Hogan B. L. M. The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells. (2009) Development 136, 3741-3745. PMCID: PMC2766341.
Rawlins E. L., Okubo T., Xue Y., Brass D. M., Auten R. L., Hasegawa H., Wang F., and Hogan B.L.M. The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. (2009) Cell Stem Cell 4, 525-534. PMCID: PMC2730729.
Rock J. R., Onaitis M. W., Rawlins E. L., Lu Y., Clark C. P., Xue Y., Randell S. H., and Hogan B. L. M. Basal cells as stem cells of the mouse trachea and human airway epithelium. (2009) Proc Natl Acad Sci USA 106, 12771-5. PMCID: PMC2714281.
2008
Rawlins E. L. and Hogan B. L. M. Ciliated epithelial cell lifespan in the mouse trachea and lung. (2008) American Journal of Physiology: Lung Cell Molecular Physiology 295, L231-234. PMCID: PMC2494792.
Rawlins E. L. Lung epithelial progenitor cells: lessons from development. (2008) Proc Am Thorac Soc. 5, 675-81. PMCID: PMC2645259. (Review article).
Rawlins E.L., Okubo T., Que J., Xue Y., Clark C., Luo X., Hogan B.L. Epithelial stem/progenitor cells in lung postnatal growth, maintenance, and repair. (2008) Cold Spring Harb Symp Quant Biol. 73, 291-295 (Review article).
2007
Rawlins E. L., Ostrowski L. E., Randell S. H., and Hogan B. L. M. Lung development and repair: contribution of the ciliated lineage. (2007) Proc Natl Acad Sci USA 104, 410-417. PMCID: PMC1752191.
2005
Rawlins E. L. and Hogan B. L. M. Intercellular growth factor signalling and the development of mouse tracheal submucosal glands. (2005) Developmental Dynamics 233, 1378-85.